Journal article
Copper-Catalyzed Alkynylation of Benzylic C–H Bonds with Alkynylboronic Esters
In
Synlett
—
2022, Volume 33, Issue 2, pp. 150-154
Abstract
We report a simple method for copper-catalyzed benzylic C–H alkynylation that uses alkynylboronic esters as nucleophilic coupling partners. The catalytic system is readily available and the reaction takes place under mild conditions. Different substrates for the C–H functionalization, as well as various alkynylboronic ester nucleophiles, were evaluated.
Finally, three examples of enantioselective C–H alkynylations are presented.
| Language: | English |
|---|---|
| Publisher: | Georg Thieme Verlag KG |
| Year: | 2022 |
| Pages: | 150-154 |
| ISSN: | 14372096 and 09365214 |
| Types: | Journal article |
| DOI: | 10.1055/s-0040-1720474 |
| ORCIDs: | Buendia, Mikkel Burggraaf , Kramer, Søren and 0000-0003-2748-5223 |
