Journal article
A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Metagenomics, Department of Bio and Health Informatics, Technical University of Denmark1
Department of Chemical and Biochemical Engineering, Technical University of Denmark2
Disease Systems Immunology, Section for Protein Science and Biotherapeutics, Department of Biotechnology and Biomedicine, Technical University of Denmark3
Department of Biotechnology and Biomedicine, Technical University of Denmark4
Copenhagen University Hospital Herlev and Gentofte5
Technical University of Denmark6
Statens Serum Institut7
Chalmers University of Technology8
The University of Auckland9
Rigshospitalet10
Research Centre for Prevention and Health11
Department of Bio and Health Informatics, Technical University of Denmark12
Capital Region of Denmark13
Clinical Microbiomics A/S14
Disease Intelligence and Molecular Evolution, Department of Bio and Health Informatics, Technical University of Denmark15
National Food Institute, Technical University of Denmark16
Research Group for Gut Microbiology and Immunology, National Food Institute, Technical University of Denmark17
University of Copenhagen18
KU Leuven19
University of Southern Denmark20
Research Group for Analytical Food Chemistry, National Food Institute, Technical University of Denmark21
Bispebjerg University Hospital22
...and 12 moreAdherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day).
We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
| Language: | English |
|---|---|
| Publisher: | Nature Publishing Group UK |
| Year: | 2018 |
| Pages: | 4630 |
| ISSN: | 20411723 |
| Types: | Journal article |
| DOI: | 10.1038/s41467-018-07019-x |
| ORCIDs: | 0000-0002-4616-7602 , 0000-0002-4999-1218 , Bahl, Martin Iain , 0000-0002-2066-7895 , Moll, Janne Marie , Meyer, Anne S. , 0000-0001-8951-6705 , 0000-0002-0994-0184 , 0000-0002-5095-0624 , 0000-0002-6024-0917 , 0000-0003-3090-269X , 0000-0001-8748-3831 , Gupta, Ramneek , Licht, Tine Rask , Roager, Henrik M. , Frandsen, Henrik L , Holck, Jesper , Hoppe, Camilla , 0000-0002-0065-8174 , 0000-0002-2495-2511 , 0000-0002-6880-5759 , 0000-0001-8509-2036 , 0000-0001-6853-3805 , 0000-0001-6476-9546 , 0000-0003-1191-373X , 0000-0001-7184-5949 and 0000-0002-3321-3972 |
Adult Aged Body Mass Index Creatinine Cross-Over Studies Cytokines DNA, Bacterial Denmark Diet Dietary fibres Faculty of Science Fasting Feces Female Fermentation Gastrointestinal Microbiome Glutens Humans Hydrogen Intestinal microbiome Intestines Low-gluten diet Male Metabolomics Metagenomics Middle Aged Postprandial Period Q Science Self Report Young Adult
