Journal article
Adjuvants and delivery systems in veterinary vaccinology: current state and future developments
Innate Immunology, Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark1
Division of Veterinary Diagnostics and Research, National Veterinary Institute, Technical University of Denmark2
National Veterinary Institute, Technical University of Denmark3
Centre de cooperation Internationale en Recherche Agronomique pour le Développement4
Animal Health and Veterinary Laboratories Agency5
Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail6
Instituto Zooprofilattico Sperimentale delle Venezie7
Friedrich-Loeffler-Institute8
Modern adjuvants should induce strong and balanced immune responses, and it is often desirable to induce specific types of immunity. As an example, efficient Th1-immunity-inducing adjuvants are highly in demand. Such adjuvants promote good cell-mediated immunity against subunit vaccines that have low immunogenicity themselves.
The development of such adjuvants may take advantage of the increased knowledge of the molecular mechanisms and factors controlling these responses. However, knowledge of such molecular details of immune mechanisms is relatively scarce for species other than humans and laboratory rodents, and in addition, there are special considerations pertaining to the use of adjuvants in veterinary animals, such as production and companion animals.
With a focus on veterinary animals, this review highlights a number of approaches being pursued, including cytokines, CpG oligonucleotides, microparticles and liposomes.
Language: | English |
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Publisher: | Springer Vienna |
Year: | 2011 |
Pages: | 183-202 |
Journal subtitle: | Official Journal of the Virology Division of the International Union of Microbiological Societies |
ISSN: | 14328798 and 03048608 |
Types: | Journal article |
DOI: | 10.1007/s00705-010-0863-1 |
ORCIDs: | Heegaard, Peter M. H. |
Adaptive Immunity Adjuvants, Immunologic Animals Animals, Domestic Biomedicine Bovine Leukemia Virus Bovine Viral Diarrhoea Virus CPG-oligonucleotide Drug Delivery Systems Immunity, Innate Immunity, Mucosal Infectious Diseases Interferons Intranasal Delivery Liposomes Local Reaction Medical Microbiology Microspheres Mucosal Immune Response Neoplasms Oligodeoxyribonucleotides Toll-Like Receptors Tretinoin Vaccination Vaccines Virology