Ahead of Print article ยท Journal article
Orally ingestible medical devices for gut engineering
Department of Health Technology, Technical University of Denmark1
Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark2
Nanoprobes, Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark3
Polymer Microsystems, Nanofabrication, National Centre for Nano Fabrication and Characterization, Technical University of Denmark4
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark5
National Food Institute, Technical University of Denmark6
Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From micro- to macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers.
Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions.
We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micromanipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future.
Language: | English |
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Publisher: | Elsevier B.V. |
Year: | 2020 |
Pages: | 142-154 |
ISSN: | 18728294 and 0169409x |
Types: | Ahead of Print article and Journal article |
DOI: | 10.1016/j.addr.2020.05.004 |
ORCIDs: | Mandsberg, Nikolaj Kofoed , Christfort, Juliane Fjelrad , 0000-0003-1754-3434 , Boisen, Anja and Srivastava, Sarvesh Kumar |