Conference paper · Book chapter
A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process
In this work, a plant-wide model-based shortcut approach for decision-making and operational analysis of integrated end-to-end continuous pharmaceutical processes is developed and tested. The proposed hierarchical approach is implemented through a computer-aided framework. Using concepts of Layer of Protection Analysis (LOPA) combined with Net Present Value (NPV) are embedded in the framework from a modelbased point of view to comprehensively assess the overall benefits of a specific operational point.
This in turn can be used to make an informed decision between competing operation alternatives. The application of the framework is demonstrated through a validated dynamic process model of an integrated end-to-end continuous pharmaceutical pilot plant. In this application, the implications of changing process operations from single pass operation to raw material recycling have been investigated.
Language: | English |
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Publisher: | Elsevier |
Year: | 2018 |
Pages: | 2107-2112 |
Proceedings: | 13th International Symposium on Process Systems Engineering (PSE 2018) |
Series: | Computer Aided Chemical Engineering |
ISBN: | 0444642412 , 0444642420 , 9780444642417 and 9780444642424 |
ISSN: | 15707946 |
Types: | Conference paper and Book chapter |
DOI: | 10.1016/B978-0-444-64241-7.50346-3 |
ORCIDs: | Mansouri, Seyed Soheil , Udugama, Isuru A. , Huusom, Jakob Kjøbsted and Gernaey, Krist V. |