Journal article
Serum Vaccine Antibody Concentrations in Children Exposed to Perfluorinated Compounds
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts (Dr Grandjean); Department of Environmental Medicine, University of Southern Denmark, Odense (Drs Grandjean and Nielsen); Department of Biostatistics, University of Copenhagen, Copenhagen, Denmark (Drs Andersen and Budtz-Jørgensen); Department of Epidemiology, Statens Serum Institut, Copenhagen (Dr Mølbak); Department of Occupational Medicine and Public Health, Faroese Hospital System, Tórshavn, Faroe Islands (Dr Weihe); and Pediatric Clinic, Rigshospitalet—National University Hospital, Copenhagen (Dr Heilmann)
Perfluorinated compounds (PFCs) have emerged as important food contaminants. They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood. To determine whether PFC exposure is associated with antibody response to childhood vaccinations.
Prospective study of a birth cohort from the National Hospital in the Faroe Islands. A total of 656 consecutive singleton births were recruited during 1997-2000, and 587 participated in follow-up through 2008. Serum antibody concentrations against tetanus and diphtheria toxoids at ages 5 and 7 years.
Similar to results of prior studies in the United States, the PFCs with the highest serum concentrations were perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). Among PFCs in maternal pregnancy serum, PFOS showed the strongest negative correlations with antibody concentrations at age 5 years, for which a 2-fold greater concentration of exposure was associated with a difference of −39% (95% CI, −55% to −17%) in the diphtheria antibody concentration.
PFCs in the child’s serum at age 5 years showed uniformly negative associations with antibody levels, especially at age 7 years, except that the tetanus antibody level following PFOS exposure was not statistically significant. In a structural equation model, a 2-fold greater concentration of major PFCs in child serum was associated with a difference of −49% (95% CI, −67% to −23%) in the overall antibody concentration.
A 2-fold increase in PFOS and PFOA concentrations at age 5 years was associated with odds ratios between 2.38 (95% CI, 0.89 to 6.35) and 4.20 (95% CI, 1.54 to 11.44) for falling below a clinically protective level of 0.1 IU/mL for tetanus and diphtheria antibodies at age 7 years. Elevated exposures to PFCs were associated with reduced humoral immune response to routine childhood immunizations in children aged 5 and 7 years.
| Language: | Undetermined |
|---|---|
| Publisher: | American Medical Association |
| Year: | 2015 |
| Pages: | 391-397 |
| ISSN: | 15383598 , 00987484 and 01851160 |
| Types: | Journal article |
| DOI: | 10.1001/jama.2011.2034 |
| ORCIDs: | Budtz-Jørgensen, Esben |
Antibody Formation Child Child, Preschool Denmark Diphtheria Toxoid Environmental Exposure Female Fluorocarbons Food Contamination Humans Immune Tolerance Immunity, Humoral Immunization Male Maternal Exposure Milk, Human Odds Ratio Polychlorinated Biphenyls Pregnancy Prenatal Exposure Delayed Effects Prospective Studies Seafood Tetanus Toxoid
