Journal article
Elaiomycins D–F, Antimicrobial and Cytotoxic Azoxides from Streptomyces sp. Strain HKI0708
In
Journal of Natural Products
—
2012, Volume 75, Issue 10, pp. 1729-1734
From
Leibniz Institute for Natural Product Research and Infection Biology1
Am Flughafen 12-14, 79108 Freiburg, Germany2
07737 Jena, Germany3
Abstract
Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure–activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.
| Language: | English |
|---|---|
| Publisher: | American Chemical Society and American Society of Pharmacognosy |
| Year: | 2012 |
| Pages: | 1729-1734 |
| ISSN: | 15206025 and 01633864 |
| Types: | Journal article |
| DOI: | 10.1021/np300329m |
