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Journal article

A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention

By Viljakainen, H.T.; Natri, A.M.; Karkkainen, M.; Huttunen, M.M.; Palssa, A.; Jakobsen, Jette1,2; Cashman, K.D.; Mølgaard, C.; Lamberg-Allardt, C.

From

Division of Food Chemistry, National Food Institute, Technical University of Denmark1

National Food Institute, Technical University of Denmark2

The effect of vitamin D supplementation on bone mineral augmentation in 212 adolescent girls with adequate calcium intake was studied in a randomized placebo-controlled setting. Bone mineral augmentation determined by DXA increased with supplementation both in the femur and the lumbar vertebrae in a dose-responsive manner.

Supplementation decreased the urinary excretion of resorption markers, but had no impact on formation markers.

Language: English
Year: 2006
Pages: 836-844
ISSN: 15234681 and 08840431
Types: Journal article
DOI: 10.1359/jbmr.060302
ORCIDs: Jakobsen, Jette and 0000-0002-5311-9457
Keywords

adequate calcium intake adolescent girls bone mineral augmentation vitamin D-3 supplementation

Other keywords

Biomarkers Calcifediol Calcification, Physiologic Calcium Child Cholecalciferol Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Female Femur Finland Humans Lumbar Vertebrae Osteogenesis Phosphates Radiography

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