Journal article
Danish Whole-Genome-Sequenced Candida albicans and Candida glabrata Samples Fit into Globally Prevalent Clades
National Food Institute, Technical University of Denmark1
Hospital of Southern Jutland2
Sydvestjysk Sygehus3
Vejle Hospital4
Hvidovre Hospital5
Research Group for Genomic Epidemiology, National Food Institute, Technical University of Denmark6
Research Group for Global Capacity Building, National Food Institute, Technical University of Denmark7
Copenhagen University Hospital Herlev and Gentofte8
Aalborg University Hospital9
Aarhus University Hospital10
Odense University Hospital11
Slagelse Hospital12
Rigshospitalet13
...and 3 moreCandida albicans and Candida glabrata are opportunistic fungal pathogens with increasing incidence worldwide and higher-than-expected prevalence in Denmark. We whole-genome sequenced yeast isolates collected from Danish Clinical Microbiology Laboratories to obtain an overview of the Candida population in the country.
The majority of the 30 C. albicans isolates were found to belong to three globally prevalent clades, and, with one exception, the remaining isolates were also predicted to cluster with samples from other geographical locations. Similarly, most of the eight C. glabrata isolates were predicted to be prevalent subtypes.
Antifungal susceptibility testing proved all C. albicans isolates to be susceptible to both azoles and echinocandins. Two C. glabrata isolates presented azole-resistant phenotypes, yet all were susceptible to echinocandins. There is no indication of causality between population structure and resistance phenotypes for either species.
Language: | English |
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Publisher: | MDPI AG |
Year: | 2021 |
Pages: | 962 |
ISSN: | 2309608x |
Types: | Journal article |
DOI: | 10.3390/jof7110962 |
ORCIDs: | Szarvas, Judit , Rebelo, Ana Rita , Leekitcharoenphon, Pimlapas , 0000-0002-2370-417X , 0000-0001-5520-106X , 0000-0002-4966-8453 , Bortolaia, Valeria and Aarestrup, Frank Møller |