Journal article
Synthesis of new diverse macrocycles from diol precursors
The formation of a library of diverse macrocycles with different ring sizes from two easily accessible building blocks is presented. Reacting diol precursors with electrophilic reagents lead to 17-membered sulfites and 19-membered malonates in 34–79% yield. Double-reductive amination of dialdehyde analogs of the diol precursors leads to 15-membered amines in yields ranging from 9 to 60%, reflecting large differences in reactivity based on steric environment.
Language: | English |
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Year: | 2010 |
Pages: | 9849-9859 |
ISSN: | 14645416 and 00404020 |
Types: | Journal article |
DOI: | 10.1016/j.tet.2010.10.071 |
ORCIDs: | Clausen, Mads Hartvig |