Journal article
Unprecedentedly mild direct Pd-catalyzed arylation of oxazolo[4,5-b]pyridine
Pd-catalyzed C-2 arylation of oxazolo[4,5-b]pyridine proceeds efficiently at 30 degrees C and tolerates a variety of aryl halides, including derivatized amino acids for which no racemization was observed during the reaction. Experimental evidence for facile deprotonation of oxazolo[4,5-b]pyridine under the reaction conditions is presented and the nature of the anionic intermediates is computationally examined. (c) 2006 Elsevier Ltd.
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Language: | English |
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Year: | 2006 |
Pages: | 2929-2932 |
ISSN: | 18733581 and 00404039 |
Types: | Journal article |
DOI: | 10.1016/j.tetlet.2006.02.117 |
ORCIDs: | Zhuravlev, Fedor |