Conference paper
Polymorphisms in the fatty acid desaturase genes and diet are important determinants of infant docosahexaenoic acid status
Tissue docosahexaenoic acid (DHA) accretion in early infancy is supported by DHA in breast-milk and may thus decrease once complementary feeding takes over. Endogenous synthesis of DHA from alphalinolenic acid is low and polymorphisms in the genes that encodes the fatty acid desaturases (FADS) has been shown to have little effect on DHA-status in adults.
It is unclear to what extent endogenous DHA-synthesis contributes to infant DHAstatus. We aim to investigate the role of diet and FADS-polymorphisms on DHA-status at 9 months and 3 years. Methods: This cross-sectional study with Danish infants use data from two prospective studies (EFiON and the SKOTcohort).
We measured erythrocyte (RBC) DHA-status at 9 months (n=409) and 3 years (n=176) and genotyped 4 FADS tagSNPs, rs3834458, rs1535, rs174575 and rs174448 (n=401).
Language: | English |
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Year: | 2013 |
Pages: | 320-321 |
Proceedings: | IUNS 20th International Congress of Nutrition |
ISSN: | 14219697 , 10189688 and 02506807 |
Types: | Conference paper |
ORCIDs: | 0000-0001-7184-5949 , 0000-0001-8827-7992 , 0000-0002-5095-0624 and 0000-0003-0449-0839 |