Journal article
Universal Behavior of Membranes with Sterols
Colloids and Biological Interfaces Group, Self-organizing materials for nanotechnology Section, Department of Micro- and Nanotechnology, Technical University of Denmark1
Self-organizing materials for nanotechnology Section, Department of Micro- and Nanotechnology, Technical University of Denmark2
Department of Micro- and Nanotechnology, Technical University of Denmark3
University of Southern Denmark4
Simon Fraser University5
National Central University6
Lanosterol is the biosynthetic precursor of cholesterol and ergosterol, sterols that predominate in the membranes of mammals and lower eukaryotes, respectively. These three sterols are structurally quite similar, yet their relative effects on membranes have been shown to differ. Here we study the effects of cholesterol, lanosterol, and ergosterol on 1-palmitoyl-2- oleoyl-sn-glycero-3-phosphatidylcholine lipid bilayers at room temperature.
Micropipette aspiration is used to determine membrane material properties (area compressibility modulus), and information about lipid chain order (first moments) is obtained from deuterium nuclear magnetic resonance. We compare these results, along with data for membrane-bending rigidity, to explore the relationship between membrane hydrophobic thickness and elastic properties.
Together, such diverse approaches demonstrate that membrane properties are affected to different degrees by these structurally distinct sterols, yet nonetheless exhibit universal behavior.
| Language: | English |
|---|---|
| Publisher: | Biophysical Society |
| Year: | 2006 |
| Pages: | 1639-1649 |
| ISSN: | 15420086 , 00063495 and 05236800 |
| Types: | Journal article |
| DOI: | 10.1529/biophysj.105.067652 |
| ORCIDs: | Henriksen, Jonas Rosager |
