Journal article
System-level understanding of gene expression and regulation for engineering secondary metabolite production in Streptomyces
Korea Advanced Institute of Science and Technology1
Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark2
Big Data 2 Knowledge, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3
Network Reconstruction in Silico Biology, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4
The gram-positive bacterium, Streptomyces, is noticed for its ability to produce a wide array of pharmaceutically active compounds through secondary metabolism. To discover novel bioactive secondary metabolites and increase the production, Streptomyces species have been extensively studied for the past decades.
Among the cellular components, RNA molecules play important roles as the messengers for gene expression and diverse regulations taking place at the RNA level. Thus, the analysis of RNA-level regulation is critical to understanding the regulation of Streptomyces’ metabolism and secondary metabolite production.
A dramatic advance in Streptomyces research was made recently, by exploiting high-throughput technology to systematically understand RNA levels. In this review, we describe the current status of the system-wide investigation of Streptomyces in terms of RNA, toward expansion of its genetic potential for secondary metabolite synthesis.
Language: | English |
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Publisher: | Springer International Publishing |
Year: | 2020 |
Pages: | 739-752 |
Journal subtitle: | Official Journal of the Society for Industrial Microbiology and Biotechnology |
ISSN: | 14765535 and 13675435 |
Types: | Journal article |
DOI: | 10.1007/s10295-020-02298-0 |
ORCIDs: | 0000-0003-4788-4184 and Palsson, Bernhard O. |