Journal article
On the present and future of dissolution-DNP
Dissolution-DNP is a method to create solutions of molecules with nuclear spin polarization close to unity. The many orders of magnitude signal enhancement have enabled many new applications, in particular in vivo MR metabolic imaging. The method relies on solid state dynamic nuclear polarization at low temperature followed by a dissolution to produce the room temperature solution of highly polarized spins.
This work describes the present and future of dissolution-DNP in the mind of the author. The article describes some of the current trends in the field as well as outlines some of the areas where new ideas will make an impact. Most certainly, the future will take unpredicted directions, but hopefully the thoughts presented here will stimulate new ideas that can further advance the field. (C) 2016 Elsevier Inc.
All rights reserved.
| Language: | English |
|---|---|
| Year: | 2016 |
| Pages: | 3-12 |
| ISSN: | 10960856 and 10907807 |
| Types: | Journal article |
| DOI: | 10.1016/j.jmr.2016.01.015 |
| ORCIDs: | Ardenkjær-Larsen, Jan Henrik |
BIOCHEMICAL Biochemistry Biophysics Condensed Matter Physics DYNAMIC-NUCLEAR-POLARIZATION Dissolution Dissolution DNP Dissolution-DNP HYPERPOLARIZATION Hyperpolarization INJECTION LIQUID-STATE NMR MR metabolic imaging MRI Magnetic resonance spectrometers, auxiliary instruments and techniques Metabolic imaging Nuclear and High Energy Physics Nuclear-spin polarization Orders of magnitude PARA-HYDROGEN PERFORMANCE PHYSICS, Polarization Polarizer RESONANCE SENSITIVITY SPECTROSCOPY Signal enhancement Solid state dynamics Spin polarization Temperature dissolution-DNP dynamic nuclear polarisation magnetic resonance imaging magnitude signal enhancement nuclear spin polarization solid state dynamic nuclear polarization
