Journal article
Fragment-based drug discovery for RNA targets
Rapid development within the fields of both fragment-based drug discovery (FBDD) and medicinal targeting of RNA provides possibilities for combining technologies and methods in novel ways. This review provides an overview of fragment-based screening (FBS) against RNA targets, including a discussion of the most recently used screening and hit validation methods such as NMR, X-ray crystallography, and virtual screening methods.
A discussion of fragment library design based on research from small molecule RNA binders provides an overview on both the currently limited guidelines within RNA-targeting fragment library design, and future possibilities. Finally, future perspectives are provided on screening and hit validation methods not yet used in combination with both fragment screening and RNA-targets.
Language: | English |
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Year: | 2021 |
Pages: | 2588-2603 |
ISSN: | 18607187 and 18607179 |
Types: | Journal article |
DOI: | 10.1002/cmdc.202100324 |
ORCIDs: | Lundquist, Kasper Plenov , Gotfredsen, Charlotte Held , Clausen, Mads Hartvig , 0000-0001-9776-1102 and 0000-0002-6204-5488 |