Journal article
A new look at lipid-membrane structure in relation to drug research
Lipid-bilayer membranes are key objects in drug research in relation to (i) interaction of drugs with membrane-bound receptors, (ii) drug targeting, penetration, and permeation of cell membranes, and (iii) use of liposomes in micro-encapsulation technologies for drug delivery. Rational design of new drugs and drug-delivery systems therefore requries insight into the physical properties of lipid-bilayer membranes.
This mini-review provides a perspective on the current view of lipid-bilayer structure and dynamics based on information obtained from a variety of recent experimental and theoretical studies. Special attention is paid to trans-bilayer structure, lateral molecular organization of the lipid bilayer, lipid-mediated protein assembly, and lipid-bilayer permeability.
It is argued that lipids play a major role in lipid membrane-organization and functionality.
| Language: | English |
|---|---|
| Publisher: | Kluwer Academic Publishers-Plenum Publishers |
| Year: | 1998 |
| Pages: | 1507-1519 |
| Journal subtitle: | An Official Journal of the American Association of Pharmaceutical Scientists |
| ISSN: | 1573904x and 07248741 |
| Types: | Journal article |
| DOI: | 10.1023/A:1011986613392 |
| ORCIDs: | 0000-0002-4258-8960 |
Animals Biochemistry, general Biomedical Engineering Biomedicine Cell Membrane Drug Carriers Humans Lipid Bilayers Lipid bilayer Lipid-protein interaction Liposomes Medical Law Membrane Lipids Membrane Proteins Molecular organization Permeability Pharmacology/Toxicology Pharmacy Phase transitions lipid bilayer lipid-protein interaction molecular organization permeability phase transitions
