Journal article
The comparison of thrombocytosis and platelet-lymphocyte ratio as potential prognostic markers in colorectal cancer
Semmelweis University1
Department of Systems Biology, Technical University of Denmark2
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark3
Tumorgenetika4
Uzsoki Memorial Hospital5
Cancer Systems Biology, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark6
Harvard University7
The aim of the present study was to analyse the preoperative platelet count and the platelet-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC) of different stages and with hepatic metastasis of CRC (mCRC) and to compare these factors as potential prognostic markers. Clinicopathological data of 10 years were collected retrospectively from 336 patients with CRC and 118 patients with mCRC.
Both in the CRC and the mCRC group overall survival (OS) was significantly worse in patients who had elevated platelet count (hazard ratio [HR] = 2.2, p <0.001 and HR = 2.9, p = 0.018, respectively). Multivariate analysis indicated that elevated platelet count was an independent prognostic factor of CRC (HR = 1.7, p = 0.035) and mCRC (HR = 3.1, p = 0.017).
Disease-free survival (DFS) was significantly worse in patients with elevated platelet count in the CRC group (HR = 2.0, p = 0.011). In the multivariate analysis the PLR was not a prognostic factor in either of the two cohorts (HR = 0.92, p <0.001 and HR = 0.89, p = 0.789, respectively). The platelet count is a valuable prognostic marker for the survival in patients both with CRC and mCRC while the PLR is not prognostic in either group.
Language: | English |
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Publisher: | Schattauer GmbH |
Year: | 2014 |
Pages: | 483-490 |
ISSN: | 2567689x , 03406245 and 03447618 |
Types: | Journal article |
DOI: | 10.1160/TH13-08-0632 |
ORCIDs: | Eklund, Aron Charles |
Aged Biomarkers, Tumor Blood Platelets Carcinoma Colorectal Neoplasms Female Humans Liver Neoplasms Lymphocytes Male Middle Aged Neoplasm Staging Platelet Activation Platelet Count Platelet-lymphocyte ratio Prognosis Retrospective Studies Survival Analysis Thrombocytosis colorectal cancer survival thrombocytosis