Journal article
Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040
Department of Biotechnology and Biomedicine, Technical University of Denmark1
Bacterial Ecophysiology and Biotechnology, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark2
University of Aberdeen3
University of Tromsø – The Arctic University of Norway4
Fundación MEDINA5
KU Leuven6
University of Coimbra7
A new siderophore containing a 4,5-dihydroimidazole moiety was isolated from Pseudoalteromonas piscicida S2040 together with myxochelins A and B, alteramide A and its cycloaddition product, and bromo- and dibromoalterochromides. The structure of pseudochelin A was established by spectroscopic techniques including 2D NMR and MS/MS fragmentation data.
In bioassays selected fractions of the crude extract of S2040 inhibited the opportunistic pathogen Pseudomonas aeruginosa. Pseudochelin A displayed siderophore activity in the chrome azurol S assay at concentrations higher than 50 μM, and showed weak activity against the fungus Aspergillus fumigatus, but did not display antibacterial, anti-inflammatory or anticonvulsant activity.
| Language: | English |
|---|---|
| Year: | 2017 |
| Pages: | 2633-2637 |
| ISSN: | 14645416 and 00404020 |
| Types: | Journal article |
| DOI: | 10.1016/j.tet.2017.03.051 |
| ORCIDs: | Sonnenschein, Eva and Gram, Lone |
