Journal article
pH-triggered drug release from biodegradable microwells for oral drug delivery
Department of Micro- and Nanotechnology, Technical University of Denmark1
Nanoprobes, Department of Micro- and Nanotechnology, Technical University of Denmark2
Saarland University3
Biomaterial Microsystems, Department of Micro- and Nanotechnology, Technical University of Denmark4
University of Copenhagen5
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark6
Microwells fabricated from poly-L-lactic acid (PLLA) were evaluated for their application as an oral drug delivery system using the amorphous sodium salt of furosemide (ASSF) as a model drug. Hot embossing of PLLA resulted in fabrication of microwells with an inner diameter of 240 μm and a height of 100 μm.
The microwells were filled with ASSF using a modified screen printing technique, followed by coating of the microwell cavities with a gastroresistant lid of Eudragit® L100. The release behavior of ASSF from the coated microwells was investigated using a μ-Diss profiler and a UV imaging system, and under conditions simulating the changing environment of the gastrointestinal tract.
Biorelevant gastric medium (pH 1.6) was employed, after which a change to biorelevant intestinal release medium (pH 6.5) was carried out. Both μ-Diss profiler and UV imaging release experiments showed that sealing of microwell cavities with an Eudragit® layer prevented drug release in biorelevant gastric medium.
An immediate release of the ASSF from coated microwells was observed in the intestinal medium. This pH-triggered release behavior demonstrates the future potential of PLLA microwells as a site-specific oral drug delivery system.
| Language: | English |
|---|---|
| Publisher: | Springer US |
| Year: | 2015 |
| Pages: | 9958 |
| Journal subtitle: | Biomems and Biomedical Nanotechnology |
| ISSN: | 15728781 and 13872176 |
| Types: | Journal article |
| DOI: | 10.1007/s10544-015-9958-5 |
| ORCIDs: | Nielsen, Line Hagner , Keller, Stephan Sylvest , Boisen, Anja , 0000-0003-3448-4237 , 0000-0002-7521-6020 and 0000-0003-3020-8892 |
Biodegradable polymer Furosemide Micro delivery systems Oral drug delivery UV imaging μ-Diss profiler
Absorbable Implants Administration, Oral Biomedical Engineering Biophysics and Biological Physics Capsules Diffusion Drug Implants Engineering Engineering Fluid Dynamics Gastric Juice Humans Hydrogen-Ion Concentration Lactic Acid Materials Testing Nanotechnology Polyesters Polymers poly(lactide)
