Journal article
Encapsulation of biomacromolecules within polymersomes by electroporation
Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process.
| Language: | English |
|---|---|
| Publisher: | WILEY‐VCH Verlag |
| Year: | 2012 |
| Pages: | 11122-11125 |
| ISSN: | 15213773 and 14337851 |
| Types: | Journal article |
| DOI: | 10.1002/anie.201204169 |
Animals Cattle DNA Electroporation HEK293 Cells Humans Immunoglobulin G Macromolecular Substances Methacrylates Muramidase Myoglobin Phosphorylcholine Polymethacrylic Acids RNA, Small Interfering Serum Albumin, Bovine drug delivery electroporation encapsulation gene therapy poly(2-(diisopropylamino)ethyl methacrylate) poly(2-methacryloyloxyethyl-phosphorylcholine) polymersomes
