Journal article
Non-Fouling Character of Poly[2-(methacryloyloxy)ethyl Phosphorylcholine]-Modified Gold Surfaces Fabricated by the 'Grafting to' Method: Comparison of its Protein Resistance with Poly(ethylene glycol)-Modified Gold Surfaces
Graduate School of Pure and Applied Science, University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki 305-8573, Japan; Center for Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba 305-8577, Japan; Tsukuba Research Center for Interdisciplinary Materials Science (TIMS), University of Tsukuba, 1-1-1 Ten-noudai, Tsukuba, Ibaraki, 305-8573, Japan.1
Poly[2-(methacryloyloxy)ethyl phosphorylcholine] -modified gold surfaces, which have been newly prepared by a 'grafting to' method using a series of monosulfanyl-terminated PMPC, are characterized by protein adsorption experiments based on surface plasmon resonance spectroscopy and ellipsometry measurements.
The extent of BSA adsorption on PMPC-modified surfaces was systematically reduced for thicker PMPC layers, thus the number of MPC units on the gold surface appears to be an important factor for the excellent protein resistance offered by PMPC-modified gold surfaces fabricated by the 'grafting to' method, which is sharp contrast to that of PEG tethered chains.
| Language: | English |
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| Publisher: | WILEY-VCH Verlag |
| Year: | 2009 |
| Pages: | 2136-2140 |
| ISSN: | 15213927 and 10221336 |
| Types: | Journal article |
| DOI: | 10.1002/marc.200900484 |
