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Journal article

Metabolic Models of Protein Allocation Call for the Kinetome

By Nilsson, Avlant1; Nielsen, Jens1,2; Palsson, Bernhard3,4,5

From

Chalmers University of Technology1

Technical University of Denmark2

Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark3

Big Data 2 Knowledge, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark4

Network Reconstruction in Silico Biology, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark5

The flux of metabolites in the living cell depend on enzyme activities. Recently, many metabolic phenotypes have been explained by computer models that incorporate enzyme activity data. To move further, the scientific community needs to measure the kinetics of all enzymes in a systematic way.

Language: English
Year: 2017
Pages: 538-541
ISSN: 24054712 and 24054720
Types: Journal article
DOI: 10.1016/j.cels.2017.11.013
ORCIDs: Palsson, Bernhard
Keywords

Animals Biological Evolution Computational Biology Computer Simulation Enzyme Activation Humans Kinetics Models, Biological Models, Theoretical Proteins Whole Genome Sequencing

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