Journal article
Sb-119 - A potent Auger emitter for targeted radionuclide therapy : Sb119-A potent Auger emitter for radionuclidetherapy
Biomedical Tracers, Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark1
Radiation Research Division, Risø National Laboratory for Sustainable Energy, Technical University of Denmark2
Risø National Laboratory for Sustainable Energy, Technical University of Denmark3
Auger electron emitting radionuclides in cancer therapy offer the opportunity to deliver a high radiation dose to the tumor cells with high radiotoxicity while minimizing toxicity to normal tissue. We have in this study identified the Auger emitter 119Sb as a potent nuclide for targeted radionuclide therapy based on theoretical dosimetry calculations at a subcellular scale.
From these calculations we have determined the cellular S-values for this therapeutic isotope. Moreover, we have demonstrated the possibility of producing this isotope and also the SPECT-analogue 117Sb for patient-specific dosimetry, by measuring the proton irradiation yields for both isotopes using a low-energy cyclotron.
The excellent SPECT imaging properties of the 117Sb radionuclide have been shown by scanning a Jaszczak SPECT Phantom.
| Language: | English |
|---|---|
| Publisher: | American Association of Physicists in Medicine |
| Year: | 2008 |
| Pages: | 3839-3846 |
| ISSN: | 24734209 and 00942405 |
| Types: | Journal article |
| DOI: | 10.1118/1.2963993 |
| ORCIDs: | Jensen, Mikael |
Antimony Auger effect Auger electrons Biological complexity Cancer Cell nucleus Dosimetry Dosimetry/exposure assessment Electrons Humans Isotopes Jaszczak phantom Medical imaging Phantoms, Imaging Protons Radioactivity Radioisotopes Radiopharmaceuticals SPECT Sb‐117 Sb‐119 Single photon emission computed tomography Single photon emission computed tomography (SPECT) S‐values Therapeutic applications, including brachytherapy Tin Tissues Tomography, Emission-Computed, Single-Photon antimony cancer cellular biophysics dosimetry phantoms planar scintigraphy production yield radiation therapy radioisotopes radionuclide therapy single photon emission computed tomography toxicology tumours
