Journal article
Total and inorganic arsenic in dietary supplements based on herbs, other botanicals and algae—a possible contributor to inorganic arsenic exposure
The content of total and inorganic arsenic was determined in 16 dietary supplements based on herbs, other botanicals and algae purchased on the Danish market. The dietary supplements originated from various regions, including Asia, Europe and USA. The contents of total and inorganic arsenic was determined by inductively coupled plasma mass spectrometry (ICP-MS) and anion exchange HPLC-ICP-MS, respectively, were in the range of 0.58 to 5.0 mgkg−1 and 0.03 to 3.2 mg kg−1, respectively, with a ratio between inorganic arsenic and total arsenic ranging between 5 and 100 %.
Consumption of the recommended dose of the individual dietary supplement would lead to an exposure to inorganic arsenic within the range of 0.07 to 13 μg day−1. Such exposure from dietary supplements would in worst case constitute 62.4 % of the range of benchmark dose lower confidence limit values (BMDL01 at 0.3 to 8 μg kg bw−1 kg−1 day−1) put down by European Food Safety Authority (EFSA) in 2009, for cancers of the lung, skin and bladder, as well as skin lesions.
Hence, the results demonstrate that consumption of certain dietary supplements could contribute significantly to the dietary exposure to inorganic arsenic at levels close to the toxicological limits established by EFSA.
Language: | English |
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Publisher: | Springer-Verlag |
Year: | 2013 |
Pages: | 4429-4435 |
ISSN: | 16182650 , 16182642 and 09390065 |
Types: | Journal article |
DOI: | 10.1007/s00216-013-6835-z |
ORCIDs: | Sloth, Jens Jørgen |
Dietary exposure Dietary supplements HPLC-ICP-MS Inorganic arsenic SDG 3 - Good Health and Well-being Speciation analysis
Analytical Chemistry Arsenic Arsenic Poisoning Arsenicals Biochemistry, general Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Chlorella Chromatography, High Pressure Liquid Denmark Dietary Supplements Environmental Monitoring/Analysis Food Contamination Food Safety Food Science Government Regulation Humans Laboratory Medicine Plant Preparations Spectrophotometry, Atomic Spirulina