Journal article
Stepping stones to the future of haemoglobin-based blood products: clinical, preclinical and innovative examples
Department of Health Technology, Technical University of Denmark1
Immunobiology and Biomimetics, Department of Health Technology, Technical University of Denmark2
Biomimetrics, Biocarriers and Bioimplants, Immunobiology and Biomimetics, Department of Health Technology, Technical University of Denmark3
Polymer Cell, Immunobiology and Biomimetics, Department of Health Technology, Technical University of Denmark4
Biomaterial Microsystems, Nanofabrication, National Centre for Nano Fabrication and Characterization, Technical University of Denmark5
There is an enormous demand for blood transfusions in daily clinical practices since blood products, especially red blood cells (RBCs), can significantly improve survival. However, donor-derived RBCs have important limitations as a result of their insufficient availability, the need for typing and cross-matching, short shelf-life or risk of pathogenic contamination.
Thus, as a result of the unique oxygen-transport ability of hemoglobin (Hb), Hb-based oxygen carriers (HBOCs) have attracted a lot of attention for the development of RBC surrogates able to provide tissue oxygenation. Here, we highlight the progress in the development of HBOCs, focusing on different examples that have undergone exhaustive pre-clinical and clinical evaluation.
In addition, we also provide a comprehensive review of very recent and innovative examples to aid in the development of the next generation of blood substitutes.
Language: | English |
---|---|
Year: | 2021 |
Pages: | 1135-1152 |
ISSN: | 20474849 and 20474830 |
Types: | Journal article |
DOI: | 10.1039/d0bm01767a |
ORCIDs: | Satué, Clara Coll , Hosta-Rigau, Leticia , 0000-0003-0116-9572 and 0000-0001-9432-1486 |