Journal article
Sulfated polysaccharide-based scaffolds for orthopaedic tissue engineering
University of Wollongong1
Technical University of Denmark2
Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark3
University of the Basque Country4
University of New South Wales5
Biologically Inspired Material Engineering, Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark6
Department of Health Technology, Technical University of Denmark7
Given their native-like biological properties, high growth factor retention capacity and porous nature, sulfated-polysaccharide-based scaffolds hold great promise for a number of tissue engineering applications. Specifically, as they mimic important properties of tissues such as bone and cartilage they are ideal for orthopaedic tissue engineering.
Their biomimicry properties encompass important cell-binding motifs, native-like mechanical properties, designated sites for bone mineralization and strong growth factor binding and signalling capacity. Even so, scientists in the field have just recently begun to utilise them as building blocks for tissue engineering scaffolds.
Most of these efforts have so far been directed towards in vitro studies, and for these reasons the clinical gap is still substantial. With this review paper, we have tried to highlight some of the important chemical, physical and biological features of sulfated-polysaccharides in relation to their chondrogenic and osteogenic inducing capacity.
Additionally, their usage in various in vivo model systems is discussed. The clinical studies reviewed herein paint a promising picture heralding a brave new world for orthopaedic tissue engineering.
Language: | English |
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Year: | 2019 |
Pages: | 119214 |
ISSN: | 18785905 and 01429612 |
Types: | Journal article |
DOI: | 10.1016/j.biomaterials.2019.05.025 |
ORCIDs: | Mehrali, Mehdi and Dolatshahi-Pirouz, Alireza |