Journal article
A self-healable, moldable and bioactive biomaterial gum for personalised and wearable drug delivery
Department of Health Technology, Technical University of Denmark1
Université catholique de Louvain2
Biologically Inspired Material Engineering, Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark3
Biotherapeutic Engineering and Drug Targeting, Department of Health Technology, Technical University of Denmark4
Department of Mechanical Engineering, Technical University of Denmark5
Manufacturing Engineering, Department of Mechanical Engineering, Technical University of Denmark6
Radboud University Nijmegen7
One of the long-standing challenges in materials science involves synthesizing biomaterials that recapitulate important features of native biological tissues. Even though, the number of available biomaterials at the moment are virtually limitless, few of them has unlocked all the secrets of the human body by mimicking the combinatorial-like material properties of our tissues and organs.
Inspired by the human body, we have developed a polymeric gum, which combines stretchability, toughness, strength, flexibility, and self-healing. It also exhibits a high bioactivity that can target and eliminate bacterial infections fast and reliably. Notably, this material is moldable into almost any complex shape, and therefore suitable as a building block for wearables designed to conform directly with the curved and personalized anatomy of patients.
It also exhibits excellent drug retention and release capacity, which altogether makes it suitable for applications in personalized wearable drug-delivery devices.
Language: | English |
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Year: | 2020 |
Pages: | 4340-4356 |
ISSN: | 20507518 and 2050750x |
Types: | Journal article |
DOI: | 10.1039/c9tb02156f |
ORCIDs: | Kadumudi, Firoz Babu , Mehrali, Mehdi , Hasany, Masoud , Dolatshahi-Pirouz, Alireza , 0000-0002-4860-3017 and 0000-0003-1471-6133 |