Journal article
Hot punching for loading of biodegradable microcontainers with budesonide-Soluplus film
Nanofabrication, National Centre for Nano Fabrication and Characterization, Technical University of Denmark1
National Centre for Nano Fabrication and Characterization, Technical University of Denmark2
University of Copenhagen3
Biomaterial Microsystems, Nanofabrication, National Centre for Nano Fabrication and Characterization, Technical University of Denmark4
Center for Intelligent Drug Delivery and Sensing Using Microcontainers and Nanomechanics, Department of Health Technology, Technical University of Denmark5
Department of Health Technology, Technical University of Denmark6
Nanoprobes, Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark7
Drug Delivery and Sensing, Department of Health Technology, Technical University of Denmark8
Micro-reservoir based drug delivery systems have the potential to provide targeted drug release locally in the intestine, i.e. at the inflamed areas of the intestine of patients with inflammatory bowel disease (IBD). In this study, microcontainers with a diameter of 300 µm and a height of 100 µm, asymmetrical geometry and the possibility to provide unidirectional release, are fabricated in the biodegradable polymer poly-ɛ-caprolactone (PCL) using hot punching.
As a first step towards local treatment of IBD, a novel method for loading of microcontainers with the corticosteroid budesonide is developed. For this purpose, a budesonide-Soluplus drug-polymer film is prepared by spin coating and loaded into the microcontainer reservoirs using hot punching. The processing parameters are optimized to achieve a complete loading of a large number of containers in a single step.
A poly(lactic-co-glycolic acid) (PLGA) 50:50 lid is subsequently applied by spray coating. Solid-state characterization indicates that the drug is in an amorphous state in the drug-polymer films and the in vitro drug release profile showed a 68% release over 10 h. The results demonstrate that hot punching can be employed both as a production and loading method for PCL microcontainers with the perspective of local treatment of IBD.
Language: | English |
---|---|
Publisher: | Springer US |
Year: | 2021 |
Pages: | 37 |
Journal subtitle: | Biomems and Biomedical Nanotechnology |
ISSN: | 15728781 and 13872176 |
Types: | Journal article |
DOI: | 10.1007/s10544-021-00572-1 |
ORCIDs: | Keller, Stephan S , Petersen, Ritika S. , Boisen, Anja , 0000-0001-9505-4180 and 0000-0003-3020-8892 |