Book chapter ยท Journal article
Bioinformatics Tools for the Prediction of T-Cell Epitopes
T-cell responses are activated by specific peptides, called epitopes, presented on the cell surface by MHC molecules. Binding of peptides to the MHC is the most selective step in T-cell antigen presentation and therefore an essential factor in the selection of potential epitopes. Several in-vitro methods have been developed for the determination of peptide binding to MHC molecules, but these are all costly and time-consuming.
In consequence, significant effort has been dedicated to the development of in-silico methods to model this event. Here, we describe two such tools, NetMHCcons and NetMHCIIpan, for the prediction of peptide binding to MHC class I and class II molecules, respectively, involved in the activation pathways of CD8+ and CD4+ T cells.
Language: | English |
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Publisher: | Springer |
Year: | 2018 |
Pages: | 269-281 |
Series: | Methods in Molecular Biology |
ISSN: | 10643745 and 19406029 |
Types: | Book chapter and Journal article |
DOI: | 10.1007/978-1-4939-7841-0_18 |
ORCIDs: | Nielsen, Morten |