Conference paper
High-throughput epitope identification for snakebite antivenom
Department of Systems Biology, Technical University of Denmark1
Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark2
Regulatory Genomics, Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark3
University of Copenhagen4
University of Costa Rica5
Network Engineering of Eukaryotic Cell Factories, Department of Systems Biology, Technical University of Denmark6
Insight into the epitopic recognition pattern for polyclonal antivenoms is a strong tool for accurate prediction of antivenom cross-reactivity and provides a basis for design of novel antivenoms. In this work, a high-throughput approach was applied to characterize linear epitopes in 966 individual toxins from pit vipers (Crotalidae) using the ICP Crotalidae antivenom.
Due to an abundance of snake venom metalloproteinases and phospholipase A2s in the venoms used for production of the investigated antivenom, this study focuses on these toxin families.
| Language: | English |
|---|---|
| Year: | 2015 |
| Proceedings: | The International Sustainability Conference 2015 |
| Types: | Conference paper |
| ORCIDs: | Engmark, Mikael , De Masi, Federico , Andersen, Mikael Rørdam and Lund, Ole |
