Journal article
Computer-Aided Modelling of Short-Path Evaporation for Chemical Product Purification, Analysis and Design
An important stage in the design process for many chemical products is its manufacture where, for a class of chemical products that may be thermally unstable (such as, drugs, insecticides, flavours /fragrances, and so on), the purification step plays a major role. Short-path evaporation is a safe method, suitable for separation and purification of thermally unstable materials whose design and analysis can be efficiently performed through reliable model-based techniques.
This paper presents a generalized model for short-path evaporation and highlights its development, implementation and solution through a computer-aided modelling framework, which allows the use of systematic simulation strategies for various types of design/analysis problems. The main features of the model and the modelling framework are highlighted through two case studies: (a) the purification of a reaction mixture containing glycerol, mono-, di- and triglycerides, and (b) the recovery of a pharmaceutical product from a six-component mixture.
Validation of the short-path evaporation model is highlighted through the comparison of experimental data from an industrial pilot plant with the simulated results from the model. Also, results from model-based sensitivity analysis and design problem solution are highlighted for two case studies.
Language: | English |
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Year: | 2006 |
Pages: | 583-594 |
ISSN: | 17443563 and 02638762 |
Types: | Journal article |
DOI: | 10.1205/cherd.05210 |