Journal article
Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI
Purpose: To compare cerebral blood flow (CBF) and cerebrovascular reserve (CVR) quantification from Turbo-QUASAR (quantitative signal targeting with alternating radiofrequency labeling of arterial regions) arterial spin labeling (ASL) and single post-labeling delay pseudo-continuous ASL (PCASL). Methods: A model-based method was developed to quantify CBF and arterial transit time (ATT) from Turbo-QUASAR, including a correction for magnetization transfer effects caused by the repeated labeling pulses.
Simulations were performed to assess the accuracy of the model-based method. Data from an in vivo experiment conducted on a healthy cohort were retrospectively analyzed to compare the CBF and CVR (induced by acetazolamide) measurement from Turbo-QUASAR and PCASL on the basis of global and regional differences.
The quality of the two ASL data sets was examined using the coefficient of variation (CoV). Results: The model-based method for Turbo-QUASAR was accurate for CBF estimation (relative error was 8% for signal-to-noise ratio = 5) in simulations if the bolus duration was known. In the in vivo experiment, the mean global CVR estimated by Turbo-QUASAR and PCASL was between 63% and 64% and not significantly different.
Although global CBF values of the two ASL techniques were not significantly different, regional CBF differences were found in deep gray matter in both pre- and postacetazolamide conditions. The CoV of Turbo-QUASAR data was significantly higher than PCASL. Conclusion: Both ASL techniques were effective for quantifying CBF and CVR, despite the regional differences observed.
Although CBF estimated from Turbo-QUASAR demonstrated a higher variability than PCASL, Turbo-QUASAR offers the advantage of being able to measure and control for variation in ATT.
Language: | English |
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Publisher: | John Wiley and Sons Inc. |
Year: | 2020 |
Pages: | 731-748 |
ISSN: | 15222594 and 07403194 |
Types: | Journal article |
DOI: | 10.1002/mrm.27956 |
ORCIDs: | 0000-0002-0210-7739 , 0000-0001-8617-7752 , 0000-0002-4851-7872 , 0000-0003-1802-4214 and Petersen, Esben T. |
Arterial spin labeling Cerebral blood flow Cerebrovascular reserve Pseudo-continuous arterial spin labeling Pulsed arterial spin labeling Turbo-QUASAR
Adult Brain Cerebrovascular Circulation Female Humans Image Interpretation, Computer-Assisted Magnetic Resonance Imaging Male Middle Aged Spin Labels Turbo‐QUASAR Young Adult arterial spin labeling cerebral blood flow cerebrovascular reserve pseudo-continuous arterial spin labeling pseudo‐continuous arterial spin labeling pulsed arterial spin labeling