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10 items by relevance
1 Book chapter

Peptide Nucleic Acids

Nielsen, Peter Eigil; Püschl, Ask

Houben-weyl. Methods of Organic Chemistry. Synthesis of Peptides and Peptidomimetics — 2003, pp. 822-835

Year: 2003

Language: English

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2 Journal article

Peptide nucleic acids

Nielsen, Peter Eigil

Science and Medicine — 1998, Issue 5, pp. 47-56

PNA, antisense, antigene, antibacterial

Year: 1998

Language: English

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3 Journal article

Antisense peptide nucleic acids

Nielsen, P E

Current Opinion in Molecular Therapeutics — 2000, Volume 2, Issue 3, pp. 282-287

Within the past couple of years peptide nucleic acid (PNA) antisense and antigene technology has entered the realm of biological and preclinical studies. This is primarily due to the development of a number of novel methods for more efficient delivery of PNA oligomers to eukaryotic cells

Year: 2000

Language: English

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4 Journal article

Applications of peptide nucleic acids

Nielsen, P E

Current Opinion in Biotechnology — 1999, Volume 10, Issue 1, pp. 71-5

Several exciting new developments in the applications of the DNA mimic peptide nucleic acid (PNA) have been published recently. A possible breakthrough may have come in efforts to develop PNA into gene therapeutic drugs. In eukaryotic systems, antisense activity of PNAs (as peptide conjugates) has

Year: 1999

Language: English

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5 Book chapter

Peptide nucleic acids. Kap. 4

Nielsen, Peter Eigil

Pharmaceutical Aspects of Oligonucleotides — 2000, pp. 98-107

Year: 2000

Language: English

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6 Journal article

Peptide nucleic acids as therapeutic agents

Nielsen, P E

Current Opinion in Structural Biology — 1999, Volume 9, Issue 3, pp. 353-357

Peptide nucleic acids (PNAs) have been around for more than seven years and it was hoped, at their introduction, that they would quickly enter the fields of antisense and antigene technology and drug development. Despite their extremely favorable hybridization and stability properties, as well

Year: 1999

Language: English

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7 Journal article

Peptide nucleic acids: Analogs and derivatives

Ganesh, Krishna N.; Nielsen, Peter Eigil

Current Organic Chemistry — 2000, Issue 4, pp. 931-943

Year: 2000

Language: English

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8 Book

Peptide nucleic acids: Protocols and applications

Nielsen, Peter Eigil; Egholm, Michael

Horizon Scientific Press — 1999

Year: 1999

Language: English

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9 Journal article

Solid-phase synthesis of peptide nucleic acids

Christensen, L; Fitzpatrick, R; Gildea, B; Petersen, K H; Hansen, H F; Koch, T; et al. (5 more)

Journal of Peptide Science — 1995, Volume 1, Issue 3, pp. 175-183

Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected

Year: 1995

Language: English

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10 Journal article

Cellular delivery of peptide nucleic acids (PNAs)

Shiraishi, Takehiko; Nielsen, Peter E

Methods in Molecular Biology — 2014, Volume 1050, pp. 193-205

Cellular delivery methods are a prerequisite for cellular studies with PNA. This chapter describes PNA cellular delivery using cell-penetrating peptide (CPP)-PNA conjugates and transfection of PNA-ligand conjugates mediated by cationic lipids. Furthermore, two endosomolytic procedures employing

Year: 2014

Language: English

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