Journal article · Ahead of Print article
A human biomonitoring (HBM) Global Registry Framework: Further advancement of HBM research following the FAIR principles
National Institute of Public Health and the Environment1
University of Granada2
Federal Office of Public Health3
European Environment Agency, Denmark4
NORMAN Association5
Santé publique France6
Environmental Health Science and Research Bureau7
National Institute for Environmental Studies8
Finnish Institute of Occupational Health9
Université Paris Cité10
State Secretariat for Economic Affairs11
University of Lisbon12
Wageningen University & Research13
HSE Science and Research Centre14
National Institute of Health Dr. Ricardo Jorge15
Laboratoire National de Santé16
Research Group for Risk Benefit, National Food Institute, Technical University of Denmark17
University of Padua18
German Environment Agency19
Department of Technology, Management and Economics, Technical University of Denmark20
Sustainability, Department of Technology, Management and Economics, Technical University of Denmark21
Quantitative Sustainability Assessment, Sustainability, Society and Economics, Department of Technology, Management and Economics, Technical University of Denmark22
University of Lausanne23
Institute of Occupational Medicine24
Flemish Institute for Technological Research25
NOVA University Lisbon26
...and 16 moreData generated by the rapidly evolving human biomonitoring (HBM) programmes are providing invaluable opportunities to support and advance regulatory risk assessment and management of chemicals in occupational and environmental health domains. However, heterogeneity across studies, in terms of design, terminology, biomarker nomenclature, and data formats, limits our capacity to compare and integrate data sets retrospectively (reuse).
Registration of HBM studies is common for clinical trials; however, the study designs and resulting data collections cannot be traced easily. We argue that an HBM Global Registry Framework (HBM GRF) could be the solution to several of challenges hampering the (re)use of HBM (meta)data. The aim is to develop a global, host-independent HBM registry framework based on the use of harmonised open-access protocol templates from designing, undertaking of an HBM study to the use and possible reuse of the resulting HBM (meta)data.
This framework should apply FAIR (Findable, Accessible, Interoperable and Reusable) principles as a core data management strategy to enable the (re)use of HBM (meta)data to its full potential through the data value chain. Moreover, we believe that implementation of FAIR principles is a fundamental enabler for digital transformation within environmental health.
The HBM GRF would encompass internationally harmonised and agreed open access templates for HBM study protocols, structured web-based functionalities to deposit, find, and access harmonised protocols of HBM studies. Registration of HBM studies using the HBM GRF is anticipated to increase FAIRness of the resulting (meta)data.
It is also considered that harmonisation of existing data sets could be performed retrospectively. As a consequence, data wrangling activities to make data ready for analysis will be minimised. In addition, this framework would enable the HBM (inter)national community to trace new HBM studies already in the planning phase and their results once finalised.
The HBM GRF could also serve as a platform enhancing communication between scientists, risk assessors, and risk managers/policy makers. The planned European Partnership for the Assessment of Risk from Chemicals (PARC) work along these lines, based on the experience obtained in previous joint European initiatives.
Therefore, PARC could very well bring a first demonstration of first essential functionalities within the development of the HBM GRF.
Language: | English |
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Year: | 2021 |
Pages: | 113826 |
ISSN: | 1618131x and 14384639 |
Types: | Journal article and Ahead of Print article |
DOI: | 10.1016/j.ijheh.2021.113826 |
ORCIDs: | 0000-0002-9505-812X , Fantke, Peter , 0000-0002-9540-8513 , 0000-0002-3494-8241 , 0000-0002-2894-5044 , 0000-0001-7772-0389 , 0000-0001-8923-2999 , 0000-0002-6060-0716 , 0000-0001-9744-7332 , 0000-0002-9350-3816 , 0000-0001-7027-7935 and 0000-0001-8644-7564 |