Journal article
Rapid synthesis of macrocycles from diol precursors
A method for the formation of synthetic macrocycles with different ring sizes from diols is presented. Reacting a simple diol precursor with electrophilic reagents leads to a cyclic carbonate, sulfite or phosphate in a single step in 25-60% yield. Converting the cyclization precursor to a bis-electrophilic iodide or aldehyde enables preparation of a cyclic sulfide and amine, respectively, the latter using a double reductive amination to induce ring closure.
Language: | English |
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Year: | 2009 |
Pages: | 693-695 |
ISSN: | 18733581 and 00404039 |
Types: | Journal article |
DOI: | 10.1016/j.tetlet.2008.11.100 |
ORCIDs: | Clausen, Mads Hartvig |