Conference paper
The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient
Department of Applied Mathematics and Computer Science, Technical University of Denmark1
Visual Computing, Department of Applied Mathematics and Computer Science, Technical University of Denmark2
Swiss Federal Institute of Technology Lausanne3
Statistics and Data Analysis, Department of Applied Mathematics and Computer Science, Technical University of Denmark4
The European Synchrotron5
Lund University Hospital6
We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations.
Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.
| Language: | English |
|---|---|
| Publisher: | The International Society for Magnetic Resonance in Medicine |
| Year: | 2020 |
| Pages: | 1-3 |
| Proceedings: | 2020 ISMRM & SMRT Virtual Conference & Exhibition |
| Types: | Conference paper |
| ORCIDs: | Andersson, Mariam , Kjer, Hans Martin , Dahl, Vedrana Andersen , Dahl, Anders Bjorholm and Dyrby, Tim Bjørn |
