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Journal article

Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy

In Sleep — 2013, Volume 36, Issue 1, pp. 91-98

By Sørensen, Gertrud Laura1; Knudsen, Stine2; Petersen, Eva Rosa2; Kempfner, Jacob1,3; Gammeltoft, Steen2; Sørensen, Helge Bjarup Dissing1,3; Jennum, Poul2

From

Department of Electrical Engineering, Technical University of Denmark1

Copenhagen University Hospital Herlev and Gentofte2

Biomedical Engineering, Department of Electrical Engineering, Technical University of Denmark3

Our results show that autonomic dysfunction is part of the narcoleptic phenotype, and that hypocretin-1 deficiency is the primary predictor of this dysfunction. This finding suggests that the hypocretin system participates in the modulation of cardiovascular function at rest. CITATION: Sorensen GL; Knudsen S; Petersen ER; Kempfner J; Gammeltoft S; Sorensen HBD; Jennum P.

Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy. SLEEP 2013;36(1):91-98.

Language: English
Publisher: Associated Professional Sleep Societies, LLC
Year: 2013
Pages: 91-98
ISSN: 15509109 and 01618105
Types: Journal article
DOI: 10.5665/sleep.2308
ORCIDs: 0000-0001-6986-5254 and Sørensen, Helge Bjarup Dissing
Keywords

Adult Arousal Autonomic Nervous System Female HCRT protein, human Heart Rate Humans Intracellular Signaling Peptides and Proteins Male Narcolepsy Neuropeptides Orexins Polysomnography Sleep Stages autonomic dysfunction heart rate response hypocretin-1 narcolepsy

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