Journal article
Homology modeling of the serotonin transporter: Insights into the primary escitalopram-binding Site
The serotonin transporter (SERT) is one of the neurotransmitter transporters that plays a critical role in the regulation of endogenous amine concentrations and therefore is an important target for therapeutic agents affecting the central nervous system. The recently published, high resolution X-ray structure of the closely related amino acid transporter, Aquifex aeolicus leucine transporter (LeuT), provides an opportunity to develop a three-dimensional model of the structure of SERT.
We present herein a homology model of SERT using LeuT as the template and containing escitalopram as a bound ligand. Our model explains selectivities known from mutational studies and varying ligand data, which are discussed and illustrated in the paper.
Language: | English |
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Publisher: | WILEY-VCH Verlag |
Year: | 2007 |
Pages: | 815-826 |
ISSN: | 18607187 and 18607179 |
Types: | Journal article |
DOI: | 10.1002/cmdc.200600242 |
ORCIDs: | Peters, Günther H.j. |