Journal article
Scope and limitations of chiral bis(oxazoline) ligands in the copper-catalysed asymmetric cyclopropanation of trisubstituted alkenes
In
Tetrahedron
—
2001, Volume 57, Issue 28, pp. 6083-6088
Abstract
A series of derivatives of 3-methyl-2-buten-1-ol has been used to test the scope and limitations of the copper-catalysed asymmetric cyclopropanation of trisubstituted alkenes by ethyl diazoacetate in the presence of C-2-symmetric bis(oxazoline) ligands. In the best case, a trans/cis ratio of 91:9, with 92% ee for the major isomer, was obtained from the reaction of the p-methoxybenzoate derivative.
The highest ee was 95%, for the trans isomer of a 80:20 diastereomer mixture (acetate derivative).
| Language: | English |
|---|---|
| Year: | 2001 |
| Pages: | 6083-6088 |
| ISSN: | 14645416 and 00404020 |
| Types: | Journal article |
| DOI: | 10.1016/S0040-4020(01)00583-X |
| ORCIDs: | Tanner, David Ackland |
