Conference paper
Should these potential CMR substances have been registered under REACH?
Abstract
(Q)SAR models were applied to screen around 68,000 REACH pre-registered substances for CMR properties (carcinogenic, mutagenic or toxic to reproduction). Predictions from 14 relevant models were combined to reach overall calls for C, M and R. Combining predictions may reduce “noise” and increase accuracy in the overall call.
The Nordic substance register database (SPIN) was used to identify not registered substances where human exposure is likely to be significant. The Danish EPA may use the results for future priority setting for e.g. proposals for (harmonized) CMR-classification or targeted experimental confirmatory testing and potential inclusion on the EU CORAP list.
| Language: | English |
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| Year: | 2013 |
| Proceedings: | 49th Congress of the European Societies of Toxicology (EUROTOX) |
| Types: | Conference paper |
| ORCIDs: | Wedebye, Eva Bay , Nikolov, Nikolai Georgiev , Dybdahl, Marianne and Abildgaard Rosenberg, Sine |
