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Journal article · Conference paper

Abstract CT103: Final results for OptimalTTF-1: Optimizing Tumor Treating Fields with targeted skull remodeling surgery for first recurrence glioblastoma: Phase 1 trial

By Mikic, Nikola1; Korshoej, Anders Rosendal1; Lukacova, Slávka1; Sørensen, Jens Christian Hedemann1; Lundgaard Hansen, Frederik1; Thielscher, Axel2,3,4; Cortnum, Søren1; Guldberg, Trine Lignell5; Lassen-Ramshad, Yasmin6; Rahbek, Christian1; Severinsen, Kare Eg1; von Oettingen, Gorm1 ...and 2 more

From

Aarhus University1

Department of Health Technology, Technical University of Denmark2

Magnetic Resonance, Department of Health Technology, Technical University of Denmark3

Neurophysics, Magnetic Resonance, Department of Health Technology, Technical University of Denmark4

Champalimaud Centre for the Unknown5

Aarhus University Hospital6

We present a clinical open label, phase-1 trial (OptimalTTF-1, NCT02893137), which aims to test a novel treatment for first recurrence glioblastoma (rGBM). The aim of the treatment is to optimize the electric field generated by Tumor Treating Fields (TTFields) with targeted and individualized skull-remodeling surgery (SR-surgery).

Selectively placed burrholes reduces the electric resistance created by the bone and thus improves the electric field focally. Preclinical research has indicated this conclusion. The final analysis examined the toxicity and efficacy of this combined intervention in addition to best practice chemotherapy.

Language: English
Year: 2020
Pages: CT103-CT103
Proceedings: AACR Annual Meeting 2020
ISSN: 15387445 , 00085472 and 05766656
Types: Journal article and Conference paper
DOI: 10.1158/1538-7445.AM2020-CT103
ORCIDs: Thielscher, Axel , 0000-0003-4285-8171 and 0000-0001-5139-7405

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