Journal article
Trans fatty acids in adipose tissue and risk of myocardial infarction: A case-cohort study
Background The risk of coronary heart disease associated with intake of individual trans fatty acids (TFAs) is not clear. Adipose tissue content of TFAs is a biomarker of TFA intake and metabolism. Objective We investigated the rate of myocardial infarction (MI) associated with the adipose tissue content of total 18:1t, isomers of 18:1t (18:1 Δ6-10t and 18:1 Δ11t) and 18:2 Δ9c, 11t.
Methods A case-cohort study, nested within the Danish Diet, Cancer and Health cohort (n = 57,053), was conducted, which included a random sample (n = 3156) of the total cohort and all incident MI cases (n = 2148) during follow-up (14 years). Information on MI cases was obtained by linkage with nationwide registers and validated.
Adipose tissue was taken from the participants buttocks and the fatty acid composition was determined by gas chromatography. Results Women with higher adipose tissue content of total 18:1t had a 57% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.57; 95% confidence interval, 1.12–2.20; P-trend = 0.011) and women with higher content of 18:1 Δ6-10t had a 76% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.76; 95% confidence interval, 1.23–2.51; P-trend = 0.002).
No association between 18:1 Δ11t content and MI rate was observed. In men, no associations between adipose tissue content of total 18:1t and 18:1 Δ6-10t and MI rate were observed. However, men with higher content of 18:1 Δ11t had a 48% higher MI rate (quintiles 5 versus 1, hazard ratio, 1.48; 95% confidence interval, 1.17–1.86; P-trend = 0.003).
Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men. Conclusions Adipose tissue content of 18:2 Δ9c, 11t was not associated with MI rate in women or men, whereas higher contents of isomers of 18:1t were associated with higher MI rates but the associations for individual 18:1t isomers differed, however, in women and men.
Language: | English |
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Publisher: | Public Library of Science |
Year: | 2018 |
Pages: | e0202363 |
ISSN: | 19326203 , 15537358 and 1553734x |
Types: | Journal article |
DOI: | 10.1371/journal.pone.0202363 |
ORCIDs: | Jakobsen, Marianne Uhre , 0000-0001-6429-7921 and 0000-0001-9389-2172 |
Adipose Tissue Adipose tissue Biomarkers Case-Control Studies Denmark Diabetes mellitus Diet Faculty of Science Fatty acids Female Humans Hypertension Isomers Male Medicine Middle Aged Myocardial Infarction Myocardial infarction Physical activity Q R Risk Factors Science Sex Factors Trans Fatty Acids adipose tissue diabetes mellitus diet fatty acids hypertension isomers myocardial infarction physical activity