Journal article
Intake of alpha-linolenic acid and risk of coronary heart disease
Research Unit for Dietary Studies at the Institute of Preventive Medicine, Copenhagen Municipal Hospitals Region H, Copenhagen, Denmark1
Section for Epidemiology, Department of Public Health, Aarhus University, Aarhus, Denmark2
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark3
Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA, USA4
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland5
Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA6
Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden7
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA8
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, USA9
Department of Epidemiology and Biostatistics, Department of Exercise Science, School of Public Health and Health Services, George Washington University, Washington, DC, USA10
National Institute of Public Health, University of Southern Denmark, Denmark11
...and 1 moreIntake of the mainly plant derived n-3 polyunsaturated fatty acid (PUFA) α-linolenic acid (ALA) has been associated with lower risk of coronary heart disease (CHD). However, the results have been inconsistent. Therefore, the objective of this study was to examine the association between ALA consumption and risk of CHD.
Potential effect modification by long-chain n-3 PUFA (n-3 LCPUFA) was also investigated. Data from eight American and European prospective cohort studies including 148,675 women and 80,368 men were used. The outcome measure was incident CHD (CHD event and death). During follow-up of 4-10 years, 4,493 CHD events and 1,751 CHD deaths occurred.
Among men we found an inverse association (not significant) between intake of ALA and CHD event and death. For each additional gram of ALA, there was a 15% lower risk of CHD events (HR: 0.85; 95% CI: 0.72, 1.01) and a 23% lower risk of CHD deaths (HR: 0.77; 95% CI 0.58, 1.01). We found no consistent associations among women.
No effect modification by intake of n-3 LCPUFA was found.
| Language: | Undetermined |
|---|---|
| Publisher: | Cambridge University Press |
| Year: | 2015 |
| Pages: | 735-743 |
| ISSN: | 14752662 and 00071145 |
| Types: | Journal article |
| DOI: | 10.1017/S000711451400138X |
| ORCIDs: | 0000-0001-7184-5949 |
