Journal article
Identification of Four New agr Quorum Sensing-Interfering Cyclodepsipeptides from a Marine Photobacterium
Department of Chemistry, Technical University of Denmark1
Organic Chemistry, Department of Chemistry, Technical University of Denmark2
University of Copenhagen3
Department of Systems Biology, Technical University of Denmark4
Natural Product Chemistry, Department of Systems Biology, Technical University of Denmark5
Bacterial Ecophysiology and Biotechnology, Department of Systems Biology, Technical University of Denmark6
During our search for new natural products from the marine environment, we discovered a wide range of cyclic peptides from a marine Photobacterium, closely related to P. halotolerans. The chemical fingerprint of the bacterium showed primarily non-ribosomal peptide synthetase (NRPS)-like compounds, including the known pyrrothine antibiotic holomycin and a wide range of peptides, from diketopiperazines to cyclodepsipeptides of 500–900 Da.
Purification of components from the pellet fraction led to the isolation and structure elucidation of four new cyclodepsipeptides, ngercheumicin F, G, H, and I. The ngercheumicins interfered with expression of virulence genes known to be controlled by the agr quorum sensing system of Staphylococcus aureus, although to a lesser extent than the previously described solonamides from the same strain of Photobacterium.
Language: | English |
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Publisher: | MDPI |
Year: | 2013 |
Pages: | 5051-5062 |
ISSN: | 16603397 |
Types: | Journal article |
DOI: | 10.3390/md11125051 |
ORCIDs: | Gram, Lone , Larsen, Thomas Ostenfeld , Gotfredsen, Charlotte Held and 0000-0002-8350-5631 |
Antivirulence Depsipeptide Photobacterium Quorum sensing SDG 14 - Life Below Water Structure elucidation agr
Anti-Bacterial Agents Bacterial Proteins Biology (General) Depsipeptides Faculty of Health and Medical Sciences Lactams Peptide Synthases QH301-705.5 Quorum Sensing Staphylococcus aureus Virulence antivirulence depsipeptide holomycin non-ribosomal peptide synthase quorum sensing structure elucidation