Conference paper
Label Free Chromosome Translocation Detection with Silicon nanowires
Department of Micro- and Nanotechnology, Technical University of Denmark1
Nano Bio Integrated Systems, Department of Micro- and Nanotechnology, Technical University of Denmark2
Surface Engineering, Department of Micro- and Nanotechnology, Technical University of Denmark3
University of Copenhagen4
Kennedy Center5
HROMOSOME translocation, which is a rearrangement of arms between two chromosomes, is a major group of chromosome abnormalities leading to cancer. As a result, two derivative chromosomes with sequences coming from both chromosomes are formed. The current translocation detection method is a Fluorescent In Situ Hybridization, which is laborious and involves use of expensive reagents [1].
Here we present a label free technique for detection of chromosome translocations. As a proof of concept detection of chromosome translocation between chromosome 3 (Chr3) and chromosome 9 (Chr9) was chosen.
| Language: | English |
|---|---|
| Year: | 2012 |
| Proceedings: | EMBS Micro- and Nanoengineering Conference |
| Types: | Conference paper |
| ORCIDs: | Castillo, Jaime and Svendsen, Winnie Edith |
