Conference paper · Journal article
Overnight Control of Blood Glucose in People with Type 1 Diabetes
Department of Informatics and Mathematical Modeling, Technical University of Denmark1
Scientific Computing, Department of Informatics and Mathematical Modeling, Technical University of Denmark2
Mathematical Statistics, Department of Informatics and Mathematical Modeling, Technical University of Denmark3
Copenhagen University Hospital Herlev and Gentofte4
Horus ApS5
Department of Systems Biology, Technical University of Denmark6
Center for Systems Microbiology, Department of Systems Biology, Technical University of Denmark7
Center for Energy Resources Engineering, Centers, Technical University of Denmark8
In this paper, we develop and test a Model Predictive Controller (MPC) for overnight stabilization of blood glucose in people with type 1 diabetes. The controller uses glucose measurements from a continuous glucose monitor (CGM) and its decisions are implemented by a continuous subcutaneous insulin infusion (CSII) pump.
Based on a priori patient information, we propose a systematic method for computation of the model parameters in the MPC. Safety layers improve the controller robustness and reduce the risk of hypoglycemia. The controller is evaluated in silico on a cohort of 100 randomly generated patients with a representative intersubject variability.
This cohort is simulated overnight with realistic variations in the insulin sensitivities and needs. Finally, we provide results for the first tests of this controller in a real clinic.
| Language: | English |
|---|---|
| Year: | 2012 |
| Pages: | 73-78 |
| Proceedings: | 8th IFAC Symposium on Biological and Medical Systems |
| Series: | Ifac Proceedings Volumes (ifac-papersonline) |
| ISBN: | 3902823100 and 9783902823106 |
| ISSN: | 14746670 |
| Types: | Conference paper and Journal article |
| DOI: | 10.3182/20120829-3-HU-2029.00106 |
| ORCIDs: | Boiroux, Dimitri , Jensen, Peter Ruhdal , Poulsen, Niels Kjølstad , Madsen, Henrik and Jørgensen, John Bagterp |
