Journal article
Review of Oxepine-Pyrimidinone-Ketopiperazine Type Nonribosomal Peptides
Department of Biotechnology and Biomedicine, Technical University of Denmark1
Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark2
Natural Product Discovery, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark3
Center for Microbial Secondary Metabolites, Centers, Technical University of Denmark4
Section for Synthetic Biology, Department of Biotechnology and Biomedicine, Technical University of Denmark5
Fungal Chemodiversity, Section for Microbial and Chemical Ecology, Department of Biotechnology and Biomedicine, Technical University of Denmark6
Recently, a rare class of nonribosomal peptides (NRPs) bearing a unique Oxepine-Pyrimidinone-Ketopiperazine (OPK) scaffold has been exclusively isolated from fungal sources. Based on the number of rings and conjugation systems on the backbone, it can be further categorized into three types A, B, and C.
These compounds have been applied to various bioassays, and some have exhibited promising bioactivities like antifungal activity against phytopathogenic fungi and transcriptional activation on liver X receptor α. This review summarizes all the research related to natural OPK NRPs, including their biological sources, chemical structures, bioassays, as well as proposed biosynthetic mechanisms from 1988 to March 2020.
The taxonomy of the fungal sources and chirality-related issues of these products are also discussed.
| Language: | English |
|---|---|
| Publisher: | MDPI |
| Year: | 2020 |
| Pages: | 246 |
| ISSN: | 22181989 |
| Types: | Journal article |
| DOI: | 10.3390/metabo10060246 |
| ORCIDs: | Guo, Yaojie , Frisvad, Jens C. and Larsen, Thomas O. |
