Journal article
Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissues
Department of Micro- and Nanotechnology, Technical University of Denmark1
Technical University of Denmark2
Aalborg University3
University of Malaya4
National Institute for Genetic Engineering and Biotechnology Iran5
Arizona State University6
Colloids and Biological Interfaces, Department of Micro- and Nanotechnology, Technical University of Denmark7
Given their highly porous nature and excellent water retention, hydrogel-based biomaterials can mimic critical properties of the native cellular environment. However, their potential to emulate the electromechanical milieu of native tissues or conform well with the curved topology of human organs needs to be further explored to address a broad range of physiological demands of the body.
In this regard, the incorporation of nanomaterials within hydrogels has shown great promise, as a simple one-step approach, to generate multifunctional scaffolds with previously unattainable biological, mechanical, and electrical properties. Here, recent advances in the fabrication and application of nanocomposite hydrogels in tissue engineering applications are described, with specific attention toward skeletal and electroactive tissues, such as cardiac, nerve, bone, cartilage, and skeletal muscle.
Additionally, some potential uses of nanoreinforced hydrogels within the emerging disciplines of cyborganics, bionics, and soft biorobotics are highlighted.
Language: | English |
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Year: | 2017 |
Pages: | 1603612 |
ISSN: | 15214095 and 09359648 |
Types: | Journal article |
DOI: | 10.1002/adma.201603612 |
ORCIDs: | Mehrali, Mehdi and Dolatshahi-Pirouz, Alireza |