Journal article · Conference paper
TANTIGEN 2.0: a knowledge base of tumor T cell antigens and epitopes
Boston University1
Department of Health Technology, Technical University of Denmark2
Bioinformatics, Department of Health Technology, Technical University of Denmark3
Single Cell Omics, Bioinformatics, Department of Health Technology, Technical University of Denmark4
Harvard University5
University of Nottingham Ningbo China6
We previously developed TANTIGEN, a comprehensive online database cataloging more than 1000 T cell epitopes and HLA ligands from 292 tumor antigens. In TANTIGEN 2.0, we significantly expanded coverage in both immune response targets (T cell epitopes and HLA ligands) and tumor antigens. It catalogs 4,296 antigen variants from 403 unique tumor antigens and more than 1500 T cell epitopes and HLA ligands.
We also included neoantigens, a class of tumor antigens generated through mutations resulting in new amino acid sequences in tumor antigens. TANTIGEN 2.0 contains validated TCR sequences specific for cognate T cell epitopes and tumor antigen gene/mRNA/protein expression information in major human cancers extracted by Human Pathology Atlas.
TANTIGEN 2.0 is a rich data resource for tumor antigens and their associated epitopes and neoepitopes. It hosts a set of tailored data analytics tools tightly integrated with the data to form meaningful analysis workflows. It is freely available at http://projects.met-hilab.org/tadb.
| Language: | English |
|---|---|
| Publisher: | BioMed Central |
| Year: | 2021 |
| Pages: | 40 |
| Proceedings: | 3rd International Workshop on Computational Methods for the Immune System Function (CMISF 2019) |
| ISSN: | 14712105 |
| Types: | Journal article and Conference paper |
| DOI: | 10.1186/s12859-021-03962-7 |
| ORCIDs: | 0000-0001-6010-490X and Olsen, Lars Rønn |
